Quick Facts
| CAS Number | 1405-41-0 (Base) / 1403-66-3 (Sulphate) |
|---|---|
| Molecular Formula | C21H43N5O7 (Gentamicin C1) · H2SO4 |
| Molecular Weight | ~575.67 (Mixture of C1, C1a, C2) |
| Pharmacopoeia | EP,BP,USP |
| Packaging | 25 KG/DRUM |
USP Standard
EP/BP Standard
GMP Certified
Product Overview
Gentamycin Sulphate (Pharma Grade) is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora purpurea. It is highly effective against aerobic Gram-negative bacilli including Pseudomonas aeruginosa, and is one of the most commonly used aminoglycosides in human medicine worldwide.
Gentamycin is a mixture of gentamicin C1, C1a, and C2 components. It binds to the 30S ribosomal subunit, causing misreading of mRNA and inhibition of protein synthesis. It demonstrates concentration-dependent bactericidal activity and is often used in combination with β-lactams for synergistic effect in severe infections.
Quality Specifications
| Purity | As per USP monograph |
|---|---|
| Residual Solvents | Compliant with ICH Q3C |
| Heavy Metals | Compliant with pharmacopoeia limits |
| GMP Status | Manufactured under GMP conditions |
Pharmaceutical Applications
- Septicemia: Severe Gram-negative bacteremia and sepsis, often in combination with β-lactams
- Hospital-acquired pneumonia: Including ventilator-associated pneumonia
- Complicated UTIs and pyelonephritis: Including multidrug-resistant infections
- Endocarditis: Combination therapy for enterococcal and staphylococcal endocarditis
- Neonatal sepsis: Empiric treatment in combination with ampicillin