Quick Facts
| CAS Number | 22189-32-8 |
|---|---|
| Molecular Formula | C14H24N2O7 · 2HCl · 5H2O |
| Molecular Weight | 495.35 |
| Pharmacopoeia | USP/IN HOUSE/EP |
| Packaging | 25 KG/DRUM |
Product Overview
Spectinomycin Hydrochloride is an aminoglycoside antibiotic produced by Streptomyces spectabilis, first discovered by Mason et al. in 1961. It demonstrates high antibacterial activity against Neisseria gonorrhoeae (including β-lactamase producing strains) and moderate activity against many Enterobacteriaceae species. It also shows good activity against Ureaplasma urealyticum.
In veterinary medicine, Spectinomycin HCl is primarily used to treat diseases caused by sensitive bacteria including E. coli, Salmonella, Pasteurella, and Mycoplasma. Its oral absorption is superior to other aminoglycosides such as neomycin sulphate, kanamycin sulphate, and gentamicin sulphate — particularly in younger animals where absorption rates are higher. It is also the safest aminoglycoside for injectable administration.
Quality Specifications
| Purity | As per USP/EP monograph |
|---|---|
| Residual Solvents | Compliant with ICH Q3C |
| Heavy Metals | Compliant with pharmacopoeia limits |
| GMP Status | Manufactured under GMP conditions |
Veterinary Applications
Soluble Powder (Poultry)
Spectinomycin 40g + Lincomycin 20g per 100g. Drinking water: 0.5-0.8g/L for 3-5 days. Injection: one bottle per 2,000-3,000 day-old chicks.
Injectable Solution
10ml: 0.5g (500,000 IU). Intramuscular injection for dogs: 0.2-0.3ml/kg, twice daily for 3 days.
Therapeutic Areas
- Poultry: E. coli infections, salmonellosis, chronic respiratory disease (CRD)
- Swine: Bacterial enteritis, pasteurellosis, mycoplasmal pneumonia
- Companion Animals: Bacterial infections susceptible to spectinomycin