Quick Facts
| CAS Number | 22189-32-8 |
|---|---|
| Molecular Formula | C14H24N2O7 · 2HCl · 5H2O |
| Molecular Weight | 495.35 |
| Pharmacopoeia | USP/IN HOUSE/EP |
| Packaging | 25 KG/DRUM |
Product Overview
Spectinomycin hydrochloride was discovered in 1961 by Mason, Dietz, and Smith at Upjohn Laboratories from the soil bacterium Streptomyces spectabilis. Unlike aminoglycosides such as gentamicin or neomycin, spectinomycin is a pure aminocyclitol — it lacks the amino sugar residues that contribute to nephrotoxicity and ototoxicity. This structural difference is why spectinomycin is the safest injectable antibiotic in the aminoglycoside-related class, with no requirement for therapeutic drug monitoring.
In poultry production, spectinomycin has been a standard treatment for chronic respiratory disease (CRD) since the 1970s. Its unique advantage over other aminoglycosides is measurable oral bioavailability — approximately 7% in adult animals and significantly higher in day-old chicks and piglets — making it effective via drinking water administration. Competing antibiotics like gentamicin remain largely confined to the gut lumen after oral dosing and cannot achieve systemic levels.
The spectinomycin + lincomycin fixed-dose combination, marketed internationally as Lincospectin and in China as Qinligao, pairs spectinomycin's Gram-negative and Mycoplasma coverage with lincomycin's Gram-positive and anaerobic spectrum. This combination covers the four major pathogen groups encountered in poultry and swine respiratory disease, making it one of the most widely prescribed veterinary antibiotic formulations in Asia, Latin America, and the Middle East.
As of mid-2026, global spectinomycin demand is driven by expanding poultry production in Southeast Asia and Africa, where CRD remains the most economically damaging respiratory disease. China accounts for the dominant share of global spectinomycin API production, with manufacturing concentrated in Shandong and Jiangsu provinces. KingWish supplies GMP-certified spectinomycin HCl backed by FDA VMF 005884 and CEP 2024-135-REV 00, supporting veterinary pharmaceutical manufacturers in regulated and emerging markets.
Quality Specifications
| Purity (HPLC) | ≥ 98.0% (anhydrous basis), per USP/EP monograph |
|---|---|
| Related Substances | Individual impurity ≤ 0.5%, total impurities ≤ 2.0% (USP) |
| Residual Solvents | Compliant with ICH Q3C; ethanol ≤ 5,000 ppm |
| Heavy Metals | ≤ 20 ppm |
| GMP Status | Manufactured under ICH Q7 GMP conditions |
| Regulatory Filings | FDA VMF 005884 (active) | CEP 2024-135-REV 00 (valid) |
Veterinary Applications
Soluble Powder (Poultry)
Spectinomycin 40g + Lincomycin 20g per 100g. Drinking water: 0.5-0.8g/L for 3-5 days. Injection: one bottle per 2,000-3,000 day-old chicks.
Injectable Solution
10ml: 0.5g (500,000 IU). Intramuscular injection for dogs: 0.2-0.3ml/kg, twice daily for 3 days.
Therapeutic Areas
- Poultry: E. coli infections, salmonellosis, chronic respiratory disease (CRD)
- Swine: Bacterial enteritis, pasteurellosis, mycoplasmal pneumonia
- Companion Animals: Bacterial infections susceptible to spectinomycin
Sourcing Spectinomycin HCl: Key Checks
Documentation
Request CoA with HPLC purity data, residual solvent statement (ICH Q3C), and GMP certificate. For regulated markets, verify VMF/DMF or CEP filing status with the supplier before placing a purchase order.
Red Flags
Inconsistently high impurity peaks on HPLC, reluctance to share batch CoA before order, vague pharmacopoeia claims ("meets USP" without test data), and prices significantly below market range.
Packaging & Logistics
Standard: 25 KG/DRUM. Custom packaging available. Verify storage conditions (room temperature, protected from moisture). Standard lead time 4–8 weeks depending on regulatory documentation requirements.
Market Context
Global spectinomycin market projected to grow steadily through 2035 driven by poultry production expansion in Southeast Asia and Africa. China dominates API production (>70% global supply). FDA VMF and CEP certifications differentiate Tier-1 suppliers from commodity producers. Market report