Quick Facts
| CAS Number | 101831-37-2 |
|---|---|
| Molecular Formula | C17H9Cl3N4O2 |
| Molecular Weight | 407.635 |
| Pharmacopoeia | CVP |
| Packaging | 25 KG/DRUM |
Product Overview
Diclazuril was developed by Janssen Pharmaceutica (a Johnson & Johnson company) in the late 1980s as a next-generation benzeneacetonitrile triazine anticoccidial. The research program that produced diclazuril and its analogue clazuril (for pigeons) represented a strategic shift from the older chemical anticoccidials (nicarbazin, amprolium, robenidine) toward high-potency synthetic compounds with wider safety margins. Janssen's pivotal broiler trials published in Poultry Science in 1989–1990 demonstrated that diclazuril at just 1 ppm in feed provided equivalent or superior coccidiosis control to ionophore antibiotics dosed at 60–125 ppm — a potency advantage of approximately 100-fold.
Diclazuril's mechanism targets a unique organelle found in apicomplexan parasites: the apicoplast. This chloroplast-like organelle (acquired through secondary endosymbiosis) is essential for fatty acid and isoprenoid biosynthesis in Eimeria species but is absent in the host animal — providing a built-in selectivity that explains diclazuril's excellent safety margin. The drug acts on both asexual schizont stages and sexual gametocyte stages, interrupting the parasite lifecycle at two critical points. This dual-stage action reduces oocyst shedding more effectively than drugs that only target early schizogony, with downstream benefits for litter contamination and flock reinfection pressure.
In commercial broiler production, diclazuril is typically administered continuously at 1 ppm in complete feed from day 1 to market. It is compatible with all commonly used feed additives including antibiotic growth promoters (where still permitted), coccidiosis vaccines, enzymes, and organic acids. The drug's negligible water solubility and poor systemic absorption mean it remains almost entirely within the intestinal lumen, eliminating residue concerns in meat and eggs. This pharmacokinetic profile earned diclazuril a zero-day withdrawal period classification in the EU and many other jurisdictions, a significant commercial advantage for integrators managing just-in-time processing schedules.
As of mid-2026, the global diclazuril market is driven by two converging trends: expanding broiler production in Southeast Asia, Africa, and Latin America, and the industry-wide shift away from antibiotic growth promoters, which increases reliance on effective chemical anticoccidials. The feed anticoccidials market, with diclazuril as a key segment, is projected to grow steadily through 2030. China accounts for the dominant share of global diclazuril API production. KingWish supplies GMP-certified diclazuril meeting CVP standards, supporting feed premix manufacturers and poultry integrators in regulated and emerging markets.
Quality Specifications
| Purity (HPLC) | ≥ 98.5% on dried basis, per CVP monograph |
|---|---|
| Related Substances | Individual impurity ≤ 0.5%, total impurities ≤ 1.5% |
| Loss on Drying | ≤ 0.5% |
| Heavy Metals | ≤ 20 ppm |
| Residual Solvents | Compliant with ICH Q3C guidelines |
| GMP Status | Manufactured under ICH Q7 GMP conditions |
Veterinary Applications
Broiler Coccidiosis Prevention
Continuous feed medication at 1 ppm (1 mg/kg feed) from day 1 to slaughter. Covers all pathogenic Eimeria species. Compatible with all standard feed additives. Zero withdrawal period for EU markets; 5-day withdrawal required per China veterinary regulations.
Layer & Breeder Protection
Safe for laying hens and breeders at recommended dose. No effect on egg production, fertility, or hatchability. No egg withdrawal period. Ideal for long-lived breeder flocks.
Therapeutic Areas
- Poultry (Broilers): Prevention of intestinal and cecal coccidiosis caused by E. tenella, E. acervulina, E. maxima, E. necatrix, E. brunetti
- Poultry (Layers/Breeders): Coccidiosis control without egg residue concerns
- Shuttle & Rotation Programs: Used in alternation with ionophores or vaccines for resistance management
Sourcing Diclazuril API: Key Checks
Documentation
Request CoA with HPLC chromatogram verifying purity and related substances. Confirm particle size data for premix blend uniformity. Verify residual solvent compliance (ICH Q3C). Request GMP certificate and batch manufacturing record summary.
Red Flags
Poor content uniformity in premix can cause under-dosing (coccidiosis breakthrough). Inconsistent particle size distribution affects blend quality. Lack of batch-specific impurity data. Prices significantly below market level.
Packaging & Logistics
Standard: 25 KG/DRUM with moisture barrier liner. Store in cool, dry conditions (below 30°C), protected from light. Micronized grades available for premix applications. Standard lead time 4–8 weeks.
Market Context
Global feed anticoccidials market projected to grow steadily through 2030. Diclazuril demand driven by broiler production expansion and NAE (No Antibiotics Ever) production systems. China dominates API supply. Market report